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In addition to reduce, each binary ufunc has an accumulate method. A call to accumulate retains all the intermediate results of the function. For example, I could determine where a running total became negative:

Current settings: Projection=UCS, Edge=Extend Select boundary edges ... Select objects or <select all>: prompt. The prompt lets you know the values of the two

constant term. Then we can use the solutions ignoring the curvature term, equations (5.15) and (5.19), to find

Next, you took a closer look at the SQL SELECT statement. You learned how to use LIMIT to restrict the number of rows returned from a query, and how to sort the rows of a result set using the ORDER BY clause. You saw how to make queries more flexible by using the LIKE and NOT LIKE operators, and how to use functions such as count(), sum(), min(), max(), and avg() to summarize columns in a table Duplicate rows can be a problem in result sets, and you saw how to solve this issue by using the

where it is assumed that the ruling lines are inclined at an angle j with respect to the y axis, as shown in Figure 9.2. This is the basic formula for the geometrical model of the Ronchi test. 9.2.1. Ronchi Patterns for Primary Aberrations Ronchi patterns obtained with primary aberrations have been stuided by may authors, as we will see later on. General treatments of them have been published by Schulz (1928), Crino (1933), Toraldo di Francia (1947, 1954) and Adachi (1960a, 1960b). The wavefront of a system with primary aberrations can be written (see Appendix 3) as W A x2 y2 2 By x2 y2 C x2 3y2 D x2 y2 9:4

6.3.2 GLOBAL REGULATIONS AND REGULATORY GUIDANCES RELEVANT TO MICROBIAL BIOBURDEN CONTROL DURING NONSTERILE MANUFACTURING GMP regulations for nished pharmaceutical drugs and components of nished drugs promulgated by the FDA [1], GMP guidelines for active pharmaceutical ingredients (Q7A) from the ICH [6], and GMP guidelines for bulk pharmaceutical excipients published by the USP [11] are discussed to illustrate the GMP requirements for pharmaceutical nished drug products, active (drug substances) and inactive (excipients) components of the drug products, respectively. In the context of this discussion on GMP regulations relevant to the microbiology of nonsterile manufacturing, contamination is de ned as the undesired introduction of impurities of a chemical or microbiological nature, or of foreign matter, into or on to a raw material, intermediate, or API during production, sampling, packaging, or repackaging, storage, or transport [6]. A similar de nition of contamination applies with reference to drug products. Microbiological bioburden refers to the level and type of microorganisms that may be present. The drug product, drug product components, manufacturing equipment, or environment can be considered contaminated when bioburden exceeds established speci cations or acceptance criteria. 6.3.2.1 GMPs for Finished Products and Components of Finished Products

Figure 3.32 A digital tele-microscopic system. (A, left): Image acquisition workstation: automatic microscope (1), CCD camera (2), video monitor (3), computer with an A/D converter attached to the CCD, image memory, and a database to manage the patient image le (4), the video monitor (3) showing a captured image from the microscope being digitized and shown on the workstation monitor (5). (A, right) Remote diagnostic workstation (6). Thumb nail images at the bottom of both workstations are the images sent to the diagnostic workstation (7) from the acquisition workstation (7). (B) Closeup of the acquisition workstation. Pertinent data related to the exam are shown in various windows. Icons on the bottom right (8) are six simple click-and-play functions: transmit, display, exit, patient information, video capture, digitize, and store. Six images had been captured and stored shown in the lower icons. The last captured image (9) is displayed on the workstation monitor. (Prototype telemicroscopic imaging system at the Laboratory for Radiological Informatic Lab, UCSF. Courtesy of Drs. S. Atwater, T. Hamill, and H. Sanchez [images], and Nikon Res. Corp. and Mitra Imag. Inc. [equipment])