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As described in 4, leptin is a 16-kDa protein secreted by adipose tissue that, in rodents, acts centrally to decrease feeding and increase sympathetically-mediated thermogenesis. Leptin therefore has the properties of a homeostatic signal that acts to indicate and maintain fat mass (Figure 21.10). Mice homozygous for ob mutations that prevent the expression of bioactive leptin show hyperphagia, decreased energy expenditure and severe obesity, with marked insulin resistance that leads to type 2 diabetes. Administering exogenous leptin reverses hyperphagia, obesity and diabetes. In humans, homozygosity for various mutations in the leptin gene LEP (OMIM 164160) has been described in a few families with a phenotype of hyperphagia soon after weaning and rapidly-progressing obesity from infancy (Montague et al., 1997) (see Figure 21.11). Other features include insulin resistance, dyslipidaemia, hypogonadotrophic hypogonadism and immune abnormalities, notably reduced circulating CD4 ve T cells and impaired T cell proliferation and cytokine release (Farooqi et al., 2002). Administration of recombinant leptin rapidly reduces hyperphagia and body weight in marked contrast to lifestyle-related obesity, in which leptin therapy is ineffective and also corrects the other phenotypic abnormalities ((Farooqi et al., 2002); see Figure 21.11). In rodents, homozygosity for mutations that disable the leptin receptor (e.g. db/db mice, fa/fa and cp/cp rats) also causes hyperphagia, obesity and severe insulin resistance, sometimes with diabetes (db/db mice) or dyslipidaemia (fa/fa and cp/cp rats). Humans homozygous for mutations of the leptin receptor (LEP-R; OMIM 601007) similarly display hyperphagia and early-onset obesity with secondary hypothyroidism and hypogonadotrophic hypogonadism (Clement et al., 1998).

R=2 R=1 R =1/2

Tip If you need to enter a coordinate that you ve typed recently, use the new Recent Input feature. Right-click and choose Recent Input from the shortcut menu. Then choose the coordinate that you want from the list that appears.

5. Explain the difference between a client/server network relationship and a client/server database system.

1. My first step was to clone the area around the neck of the statue with a soft brush shape. Abandoning the controlled clicks I recommended in the last section, I allowed myself to drag with the tool because I needed to cover relatively large portions of the image. The apartment building (or whatever that structure is) behind the floating head is magnificently out of focus, just the thing for hiding any incongruous transitions I might create with the rubber stamp. So I warmed up to the image by retouching this area first. Figure 7-13 shows my progress. I covered the workman s body by cloning pixels from both his left and right sides. I also added a vertical bar where the workman s right arm used to be to maintain the rhythm of the building. Remember, variety is the key to using the rubber stamp tool: If you consistently clone from one portion of the image, you create an obvious repetition the viewer can t help but notice.

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Figure 10.21. Transverse pro les of generated beams in different variants of the self-starting scheme with a planar cell at repetition rate 30 Hz with QR (u 908): (a) Output beam in the scheme with diaphragm; (b) output beam in the scheme without diaphragm; (c) generated beam outgoing from a 50% mirror of the scheme with diaphragm; (d) generated beam outgoing from a 50% mirror of the scheme without diaphragm.

Function WIFSTOPPED(status) WSTOPSIG(status) WIFSIGNALED(status) WTERMSIG(status) WIFEXITED(status) WEXITSTATUS(status) Value returned 1 if process was stopped (and not terminated) Signal that stopped the process if WIFSTOPPED was true 1 if process was terminated due to a signal Signal that terminated the process if WIFSIGNALED was true 1 if the process exited due to _exit() or exit() Status code if WIFEXITED was true